Cancer risk among gingivitis and periodontitis patients: a nationwide cohort study
BW Wen, CS Tsai, CL Lin, YJ Chang… - … Journal of Medicine, 2014 - academic.oup.com
QJM: An International Journal of Medicine, 2014•academic.oup.com
Aim: Periodontal disease encompasses gingivitis and periodontitis, which exerts systemic
effects. We conducted a population-based study to evaluate the association between
periodontal disease and the risk of cancer. Methods: We used insurance claims data from
1997 to 2010, accessing a database of 1 million randomly selected insurants in Taiwan. All
patients were older than 20 and newly diagnosed with periodontitis between 1 January
1997 and 31 December 2010. The comparison cohort comprised patients older than 20 …
effects. We conducted a population-based study to evaluate the association between
periodontal disease and the risk of cancer. Methods: We used insurance claims data from
1997 to 2010, accessing a database of 1 million randomly selected insurants in Taiwan. All
patients were older than 20 and newly diagnosed with periodontitis between 1 January
1997 and 31 December 2010. The comparison cohort comprised patients older than 20 …
Abstract
Aim: Periodontal disease encompasses gingivitis and periodontitis, which exerts systemic effects. We conducted a population-based study to evaluate the association between periodontal disease and the risk of cancer.
Methods: We used insurance claims data from 1997 to 2010, accessing a database of 1 million randomly selected insurants in Taiwan. All patients were older than 20 and newly diagnosed with periodontitis between 1 January 1997 and 31 December 2010. The comparison cohort comprised patients older than 20, who were newly diagnosed with gingivitis in the same period. Both cohorts were followed until a cancer diagnosis, lost to follow-up, death, termination of insurance, or the end of 2010.
Results: The incidence rate of cancer was 1.14 times higher in the study cohort than in the comparison cohort [confidence interval (CI) = 1.11–1.17]. The adjusted hazard ratio (HR) was 1.05 (95% CI = 1.00–1.11). A multivariable analysis showed that the periodontitis patients exhibited an elevated risk of developing oral cancer (adjusted HR = 1.79, 95% CI = 1.42–2.25).
Conclusion: The findings indicated that patients in the periodontitis cohort exhibited a higher risk of developing oral cancer than those in the gingivitis cohort.
Oxford University Press