Orally Administered Polysaccharide Derived from Blackcurrants (Ribes nigrum L.) Improves Skin Hydration in Ultraviolet-Irradiated Hairless Mice

J Nutr Sci Vitaminol (Tokyo). 2018;64(4):301-304. doi: 10.3177/jnsv.64.301.

Abstract

Blackcurrants (Ribes nigrum L.) have various benefits for human health. In particular, a polysaccharide derived from blackcurrant was found to be an immunostimulating food ingredient in a mouse model. We named a polysaccharide derived from blackcurrant cassis polysaccharide (CAPS). In a previous clinical study, we reported that CAPS affects skin dehydration, demonstrating its effectiveness against skin inflammation was related to atopic dermatitis; skin inflammation caused skin dehydration. However, there are no studies regarding CAPS effectiveness against skin dehydration. The current study aimed to investigate CAPS effectiveness against skin dehydration. We further demonstrate the effect of oral administration of CAPS on skin dehydration caused by ultraviolet (UV) irradiation-induced inflammation in mice. We found that CAPS administration suppresses skin dehydration caused by UV irradiation. We also found that CAPS decreases interleukin-6 and matrix metalloproteinase transcription levels in the mouse skin. These results show that CAPS improves skin hydration in UV-irradiated mice.

Keywords: blackcurrant; polysaccharide; skin hydration; ultraviolet.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Dermatitis, Atopic / etiology
  • Dermatitis, Atopic / immunology
  • Dermatitis, Atopic / metabolism
  • Dermatitis, Atopic / therapy*
  • Dietary Carbohydrates / administration & dosage
  • Dietary Carbohydrates / analysis
  • Dietary Carbohydrates / isolation & purification
  • Dietary Carbohydrates / therapeutic use*
  • Dietary Fiber / administration & dosage
  • Dietary Fiber / analysis
  • Dietary Fiber / therapeutic use
  • Dietary Supplements / analysis
  • Female
  • Fruit / chemistry*
  • Gene Expression Regulation / radiation effects
  • Interleukin-6 / antagonists & inhibitors
  • Interleukin-6 / genetics
  • Interleukin-6 / metabolism
  • Matrix Metalloproteinase 13 / chemistry
  • Matrix Metalloproteinase 13 / genetics
  • Matrix Metalloproteinase 13 / metabolism
  • Mice, Hairless
  • Plant Extracts / administration & dosage
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / therapeutic use*
  • Prebiotics / administration & dosage
  • Prebiotics / analysis
  • Radiation Injuries, Experimental / immunology
  • Radiation Injuries, Experimental / metabolism
  • Radiation Injuries, Experimental / therapy
  • Ribes / chemistry*
  • Skin / immunology
  • Skin / metabolism*
  • Skin / radiation effects
  • Specific Pathogen-Free Organisms
  • Ultraviolet Rays / adverse effects
  • Water / metabolism

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Dietary Carbohydrates
  • Dietary Fiber
  • Interleukin-6
  • Plant Extracts
  • Prebiotics
  • interleukin-6, mouse
  • Water
  • Matrix Metalloproteinase 13
  • Mmp13 protein, mouse